This problem can happen when the systems TEMP directory has the hidden file attributes.
In this case, you can try the following process :
Enter in DOS prompt the command "attrib %TEMP%" to check if the hidden attribute (H) is set. You can remove it with command "attrib %TEMP% -H".
You should then be able to register TwidoSuite.
Note: TwidoSuite and the Twido product line was obsolete in Dec. 2015 and has been replaced by EcoStruxure Machine Expert Basic (formally SoMachine Basic) and the M221 line. The software is free and the Twido program can be imported into the Eostrxure Machine Basic software.